This study builds collaborative frameworks to investigate population-specific susceptibility factors for periodontal disease in Hispanic populations. It aims to improve understanding of biological and social determinants of oral health disparities and support culturally informed, equity-focused periodontal research.
This study aims to develop and strengthen collaborative research on Grade C periodontitis (localized molar-incisor pattern, C/MIP; previously referred to as aggressive periodontitis) by expanding ongoing NIH-funded efforts (U01DE031223) to include underrepresented Hispanic populations. Building on a multi-country research program investigating genetic, microbial, and host-response factors associated with disease susceptibility, this project will establish new collaborations in Puerto Rico and the Dominican Republic. These regions represent important but understudied populations with limited representation in current datasets. The study will generate feasibility data, support training and capacity-building activities, and facilitate cross-cultural research exchange. By addressing critical gaps in population diversity within the existing U01 framework, this project seeks to enhance understanding of disease heterogeneity and contribute to more equitable and globally relevant periodontal research.
Findings from this study will improve understanding of susceptibility factors for Grade C periodontitis (localized molar-incisor pattern, C/MIP), a rapidly progressive form of periodontal disease affecting adolescents and young adults, including populations in Kentucky. The project may support earlier identification of high-risk individuals, improve understanding of genetic, microbial, and host-response contributions to disease, and enhance clinician awareness of early disease presentation. These insights can inform more timely diagnosis, targeted prevention strategies, and improved oral health education for affected youth, ultimately contributing to better clinical management and reduced tooth loss in young patients.
UKinSPIRE (Seeding Partnerships for International Research Engagement) funded by the Office of the Vice President for Research (OVPR) and the UK International Center (UKIC).