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James Hartsfield Jr., DMD, MS, MMSc, PhD, FACMG, CDABO

E. Preston Hicks Endowed Professor of Craniofacial Genetics, Orthodontics and Oral Health Research

Department: Oral Health Science


  • BS, Biology, University of South Carolina, Columbia, SC
  • DMD, Medical University of South Carolina, Charleston, SC
  • MS Indiana University, Indianapolis, IN
  • MMSc Harvard University, Boston, MA
  • PhD University of South Florida College of Medicine, Tampa, FL


  • Orthodontics, Harvard University and the Forsyth Dental Center, Boston, MA


  • Medical Genetics, Indiana University School of Medicine, Indianapolis, IN
  • Embryology-Teratology, Massachusetts General Hospital, Boston, MA
  • Clinical Genetics, University of South Florida College of Medicine, Tampa, FL

Certification/Special Training

  • American Board of Orthodontics American Board of Medical Genetics
  • Craniofacial Genetics
  • Orthodontics
  • Discovery and investigation of genetic factors associated with normal growth and pathology in dentistry and or medicine.
  • Whole Exome Sequencing of families with Class III and Class II div 2 to identify causal genes for the malocclusion (in conjunction with Dr. Lorri Morford).
  • Three-dimensional facial imaging for syndrome diagnosis; and/or orthodontic and orthognathic surgery diagnosis, treatment planning and outcome assessment. Will focus on this while on sabbatical in Western Australia for 3 months in early 2020.
  • Investigation of known genetic variants associated with variation of facial growth during puberty and the use of mandibular protrusive functional appliances (in conjunction with Dr. Lorri Morford and collaboration with Dr. Lorenzo Franchi and others). This is to help understand in pubertal growth variation seen in even compliant functional appliance (such as the twin block in Italy) patients.
  • American Dental Association, Society of Craniofacial Genetics (President 1988-1990; Now the Society of Craniofacial Genetics and Developmental Biology); International and American Associations for Dental Research (President IADR Craniofacial Biology Section 2005-2006; Member AADR Nominating Committee 2010-2013); American Society of Human Genetics; American Association of Dental Schools/American Dental Education Association; American Association of Orthodontists; World Federation of Orthodontists; Kentucky Association of Orthodontists; Southern Association of Orthodontists; Kentucky Dental Association (Bluegrass Dental Society); Edward H. Angle Society of Orthodontists (Midwest Component); American College of Medical Genetics (Founding Fellow); American College of Dentists; College of Diplomates of the American Board of Orthodontics; International College of Dentists
  • 2003 Distinguished Faculty Award for Research from the Indiana University School of Dentistry Alumni Association; 2004 Recipient of the Indiana Dental Association Outstanding Faculty Member of the Year at the Indiana University School of Dentistry; 2012 University of Kentucky Center for Clinical and Translational Science Mentor Award
  • Co-author of three entries in the Birth Defects Encyclopedia. Blackwell Scientific Publications, Inc. Cambridge, MA 1990; Chapter author in Advances in Pediatrics 1994; Co-author of a chapter in Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Harvard Soc. Adv. of Ortho, Boston, MA 2000; Co-author of three chapters in Dentistry for the Child and Adolescent, seventh, eight and ninth editions. Mosby, Inc. St. Louis, MO 2000, 2004, 2010; Co-author of a chapter in Cleft Lip and Palate. From Origin to Treatment. Oxford University Press, Oxford 2002; Co-author of a chapter in the Orthodontics Year Book '04. Quintessence Publishing Company, Tokyo 2004; Author of a chapter in Orthodontics Current Principals and Techniques, fourth and fifth editions. Mosby, Inc. St. Louis, MO 2005, 2011; Author of a chapter in Integrated Clinical Orthodontics. Wiley-Blackwell, Oxford 2012; Co-author of a chapter in Orthodontic - Basic Aspects and Clinical Considerations. InTech Press, 2012; Co-editor of and co-author of three chapters in Essentials for Orthodontic Practice, third edition. 2012; Co-editor of and co-author of one chapter in Nanobiomaterials in Clinical Dentistry. William Andrew (Elsevier), 2013; Co-author of a chapter in Class III eBook, Part II. Biological Viewpoint. Bentham, in production; Co-author of a chapter in Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Elsevier, in production.
  • Ad hoc reviewer for 29 journals in dentistry, orthodontics, medicine and genetics; and a reviewer and editorial board member for Journal of Dental Research (2007-2009); Angle Orthodontist (2011-2016); American Journal of Orthodontics and Dentofacial Orthopedics (2008-present); International Journal of Dentistry (2012-2014); Advances in Medicine (2013-2016), and Co-Editor of the Journal of Pediatric Genetics starting 2014.
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