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James Hartsfield, Jr., DMD, MS, MMSc, PhD, FACMG, CDABO, FACD, FICD

E. Preston Hicks Endowed Professor of Craniofacial Genetics, Orthodontics and Oral Health Research

Department: Oral Health Science


  • BS, Biology, University of South Carolina, Columbia, SC
  • DMD, Medical University of South Carolina, Charleston, SC
  • MS Indiana University, Indianapolis, IN
  • MMSc Harvard University, Boston, MA
  • PhD University of South Florida College of Medicine, Tampa, FL


  • Clinical Genetics, Indiana University School of Medicine, Indianapolis, IN
  • Orthodontics, Harvard University School of Dental Medicine and the Forsyth Dental Center, Boston, MA
  • Clinical Genetics, University of South Florida College of Medicine, Tampa, FL


  • Research Fellow in Pediatrics (Embryology-Teratology), Massachusetts General Hospital, Boston, MA

Certification/Special Training

  • American Board of Orthodontics
  • American Board of Medical Genetics
  • Craniofacial Genetics
  • Orthodontics
  • Discovery and investigation of genetic factors associated with normal growth and pathology in dentistry and or medicine.
  • Whole Exome Sequencing of families with Class III and Class II div 2 to identify causal genes for the malocclusion (in conjunction with Dr. Lorri Morford).
  • Three-dimensional facial imaging for syndrome diagnosis; and/or orthodontic and orthognathic surgery diagnosis, treatment planning and outcome assessment.
  • Investigation of known genetic variants associated with variation of facial growth during puberty.
  • American Dental Association, Society of Craniofacial Genetics (President 1988-1990; Now the Society of Craniofacial Genetics and Developmental Biology); International and American Associations for Dental Research (President IADR Craniofacial Biology Section 2005-2006; Member AADR Nominating Committee 2010-2013); American Society of Human Genetics; American Association of Dental Schools/American Dental Education Association; American Association of Orthodontists; World Federation of Orthodontists; Kentucky Association of Orthodontists; Southern Association of Orthodontists; Kentucky Dental Association (Bluegrass Dental Society); Edward H. Angle Society of Orthodontists (Midwest Component President 2018-2019); American College of Medical Genetics (Founding Fellow); American College of Dentists; College of Diplomates of the American Board of Orthodontics; International College of Dentists
  • 2003 Distinguished Faculty Award for Research from the Indiana University School of Dentistry Alumni Association; 2004 Recipient of the Indiana Dental Association Outstanding Faculty Member of the Year at the Indiana University School of Dentistry; 2012 University of Kentucky Center for Clinical and Translational Science Mentor Award
  • Co-author of three entries in the Birth Defects Encyclopedia. Blackwell Scientific Publications, Inc. Cambridge, MA 1990; Chapter author in Advances in Pediatrics 1994; Co-author of a chapter in Biological Mechanisms of Tooth Movement and Craniofacial Adaptation, Harvard Soc. Adv. of Ortho, Boston, MA 2000; Co-author of two chapters in Dentistry for the Child and Adolescent, seventh, eighth, ninth, tenth and eleventh editions. Mosby, Inc. St. Louis, MO 2000, 2004, 2010, 2016, 2021; Co-author of a chapter in Cleft Lip and Palate. From Origin to Treatment. Oxford University Press, Oxford 2002; Co-author of a chapter in the Orthodontics Year Book '04. Quintessence Publishing Company, Tokyo 2004; Author of a chapter in Orthodontics Current Principals and Techniques, fourth, fifth, sixth and seventh (in press) editions. Mosby, Inc. St. Louis, MO 2005, 2011, 2016, 2022; Author of a chapter in Integrated Clinical Orthodontics. Wiley-Blackwell, Oxford 2012; Co-author of a chapter in Orthodontic - Basic Aspects and Clinical Considerations. InTech Press, 2012; Co-editor of and co-author of three chapters in Essentials for Orthodontic Practice, third edition. 2012; Co-editor of and co-author of one chapter in Nanobiomaterials in Clinical Dentistry. William Andrew (Elsevier), 2013; Co-author of a chapter in Class III eBook, Part II. Biological Viewpoint. Bentham, in production; Co-author of a chapter in Osteogenesis Imperfecta: A Translational Approach to Brittle Bone Disease. Elsevier, 2013.
  • Ad hoc reviewer for 49 journals in dentistry, orthodontics, medicine and genetics; and a reviewer and editorial board member for Journal of Dental Research (2007-2009); Angle Orthodontist (2011-present); American Journal of Orthodontics and Dentofacial Orthopedics (2008-present); International Journal of Dentistry (2012-2014); Advances in Medicine (2013-2016), PLOSOne (Academic Editor 2015-2018), Journal of the World Federation of Orthodontists (2017-present) and Co-Editor of the Journal of Pediatric Genetics 2014-2017.
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