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Lorri Morford, PhD

Assistant Professor, Division of Orthodontics


Department: Oral Health Science

  • Office:412 HSRB, Lab MN279
    Lexington, Kentucky 40536
  • Phone:859-323-2595
  • Other Phone:
  • Email:lorri.morford@uky.edu

Degree

  • PhD, Immunology, University of Kentucky College of Medicine;

Certification/Special Training

  • Tumor Cell Biology, T-Lymphocyte Signaling, Molecular Biology, Genetics, Developmental Gene Regulation, Post Transcriptional Gene Regulation
  • Clinical Genetics
  • Hypodontia
  • Oligodontia
  • Class II and Class III malocclusions
  • How and why tooth anomalies, such as hypodontia and oligodontia, are associated with cancer and determine whether or not this information be utilized to improve early cancer diagnosis and treatment.
  • Genetic factors which influence facial growth and the development of dental malocclusion and/or disease. Dr. Morford specifically studies the genetics of Class III and Class II Division 2 Malocclusion.
  • Genetic predisposition for chronic inflammation (CI) across multiple disease models of CI including Rheumatoid Arthritis (RA), Periodontitis (PD) and Alzheimer’s Disease (AD).
  • The focus of this research is to (a) gain a better understanding of the genetic varation(s) that are associated with dental agenesis in specific dental fields (i.e., incisors, premolars, molars) within families and in a case/control study format, and (b) explore connections between dental agenesis (DA) early in life and cancer development later in life. (Ongoing collaborations with Dr. Jim Hartsfield at UK and Dr. Ariadne Letra at Univ of Texas Health Sciences in Houston).
  • The focus of this research is to (a) Study the phenotypic differences in craniofacial shape due to skeletal malocclusion within families and when comparing different ethnic backgrounds, (b) Identify genetic factors which drive skeletal Class II and Class III malocclusion growth patterns in families, and (c) Understand how facial shape and inherited genetic factors play a role in the success of early growth modification (Ongoing collaborations with Dr. Jim Hartsfield at UK, and other investigators from Colombia, Brazil and Italy).
  • (PILOT) The focus of this translational research is to develop a panel of genetic markers that can aid in predicting an individuals' relative risk for developing one or more chronic inflammatory disease in their lifetime (using the genetic of individuals diagnosed with periodontal disease, diabetes and/or Alzheimers Disease).
  • James K. Hartsfield Jr., Lorri Ann Morford and Liliana M. Otero (2012). Genetic Factors Affecting Facial Growth, Orthodontics - Basic Aspects and Clinical Considerations, Prof. Farid Bourzgui (Ed.)
  • Jeffery L. Ebersole, Dolphus R. Dawson III, Lorri A. Morford, Rebecca Peyyala, Craig S. Miller and Octavio A Gonzaléz (2013) Periodontal Disease Immunology: “Double Indemnity” in Protecting the Host, Periodontology 2000, Vol. 62, p 163-202.
  • Subramani K, S Huja, GT Kluemper, L Morford, JK Hartsfield Jr: Chapter 11. Nanotechnology in Orthodontics – 1: The Past, Present, and a Perspective of the Future. In: Nanobiomaterials in Clinical Dentistry. 
  • James K. Hartsfield, Lorri A. Morford, Liliana M. Otero, and David W. Fardo (2013)  Genetics and Non-Syndromic Facial Growth., Journal of Pediatric Genetics, IOS Press, J Pediatr Genet Vol. 2, Number 1.
  • Otero LM, LA Morford, G Falcão-Alencar, JK Hartsfield Jr: (2013) Chapter 1. Family History, Genetics In: Class III eBook, Part II.
  • Ad hoc reviewer for the Journal of Dental Research (JDR) and American Journal of Orthodontics and Dentofacial Orthopedics (AJODO)
  • Director, International Association of Dental Research (IADR) Craniofacial Biology Group Executive Committee
  • 2013 Moyers Symposium Junior Investigator Travel Award for best scientific work presented in the junior faculty category
  • Principle Investigator, NIDCR R03DE021438, Genetic Markers Associated with Epithelial Ovarian Cancer and Hypodontia
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